Title: Impact of Pollutants and Man-Made Chemicals on Diseases of Civilization and Human Life Expectancy
Subject Classification:  Healthcare, Science, Medicine and Medical Ethics  
BIC Classification: MB, MBP, RNP
BISAC Classification: MED025000, MED078000, SCI026000
Binding: Hardback, eBook
Planned publication date: Feb 2027
ISBN (Hardback): 978-1-83711-361-3
ISBN (eBook): 978-1-83711-362-0

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Description

The incidence of diseases of civilization (cancer, cardiovascular, neurodegenerative and immune system related diseases etc.) is increasing worldwide, in spite of markedly improved socioeconomic conditions and availability of food items. Huge differences in cancer incidence in function of time and place suggest that the present incidence of cancer is much higher than the unavoidable naturally occurring one. There is substantial evidence indicating that pollutants and man-made products contribute substantially to the risk of diseases of civilization.
Cancer rests essentially on the accumulation of mutations in several critical genes in the same cell. Even a small increase in mutations results in a strong increase in cancer incidence. Carcinogenesis and atherosclerosis, which together account for most of the mortality, have several biological mechanisms in common. Experimental studies and molecular epidemiological studies reveal that mutagenic agents and endocrine disrupting agents are often more potent per unit dose at very low concentrations, such as those occurring in real life conditions, than at higher concentrations. Also epigenetic effects potentially affecting future generations can be induced. Identification of and action on the real causes of cancer and other diseases of civilization are hampered by the enormous number of intervening substances, by conflicts of interest and scientific fraud.
Advanced epidemiological studies, and the fact that persons having more unfavorable genes concerning health effects of external chemicals have a shorter life expectancy, suggest that pollutants and man-made products might shorten life expectancy by at least 5 and probably about 10 years.
These important new insights will be of interest to researchers in public health, and medical, environmental and healthcare policy makers.

Biography

Author(s):  Dr Nicolas Van Larebeke is the author or co-author of more than 130 publications in international scientific journals including 3 papers in Nature. He was the founder of the Study Centre for Carcinogenesis and Primary Prevention of Cancer, in the Faculty of Medicine and Health Sciences, Ghent University, Belgium, where he remains an Honorary Professor.

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